BPA, bisphenol A; GPR30, G protein-coupled receptor 30; EGFR, Epidermal Growth Factor Receptor; ERK, extracellular signal-regulated kinase; RAS, Rat sarcoma; RAF, proto-oncogene serine/threonine-protein kinase; PI3K, phosphatidylinositol-3 kinase; Akt, kinase inhibiting apoptosis; mTOR, mammalian target of rapamycin; TNF-α, Tumor Necrosis Factor; IL-1, Interleukin 1; IL-6 Interleukin-6; IR, insulin resistance. The gene discussed is EGFR; the disease is Insulin resistance.