Whereas, hydatidiform moles show extreme hypomethylation of maternal imprinting marks only, NLRP5 variants cause mosaic hypomethylation affecting both maternal and paternal marks, suggesting that NLRP7 may exert its effect in the oocyte, while NLRP5′s action may be postzygotic [37]. The gene discussed is NLRP7; the disease is hydatidiform mole.