STAT1 and infection: Extant evidence (experimented upon mice) further indicates that DENV primary infection utilizes the interferon α/β receptor (IFNAR)-dependent (including STAT1-dependent and STAT1-independent) control mechanisms—where the STAT1 (Signal transducer and activator of transcription 1)-dependent mechanism controls the primary steps of infection, while the STAT1-independent mechanism controls the latter antiviral process—aiding virus propagation and disease control.