Further, somatic loss of NF1 is common and found in many different types of cancers, including up to 87% of MPNST [1], 23% of acute lymphoblastic leukemia, 12%–18% of all melanomas, 11%–18% of glioblastoma, 12% of non-small-cell lung cancer, 12% of lung squamous-cell carcinoma, 13% of lung adenocarcinoma, 10%–14% of bladder urothelial carcinoma, 14% of uterine carcinosarcoma, 11%–12% of uterine endometrial carcinoma, 12% of ovarian serous cystadenocarcinoma, 11% of pancreatic carcinoma, 10% of metastatic cutaneous squamous-cell carcinoma, and 10% of gastric adenocarcinoma (reviewed by [2]). This evidence concerns the gene NF1 and melanoma.