Venetoclax, a Bcl-2 inhibitor, in combination with azacitidine or decitabine or low-dose cytarabine is approved (conditionally) by the US Food and Drug Administration (FDA) for treatment of adult patients with newly-diagnosed AML who are age 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy [78]. This evidence concerns the gene BCL2 and acute myeloid leukemia.