In Ewing sarcoma and rhabdomyosarcoma, however, TIMP2 follows a similar pattern of low expression, as with MMP14. Interestingly, MMP2 and MMP14 genes are the first and third most significantly co-expressed genes with TIMP2 in sarcoma (TCGA-SARC) indicating that these genes share common regulation mechanisms. The gene discussed is MMP14; the disease is Ewing sarcoma.