Yet, the MMP14 gene expression across a variety of cancer types is highest in sarcomas, with the childhood rhabdomyosarcomas and Ewing sarcoma representing intriguing exceptions (Figure 1B,C, www.cbioportal.org/), suggesting that it may be a particularly important player in sarcoma biology [28,29]. This evidence concerns the gene MMP14 and rhabdomyosarcoma.