The switch from well-differentiated to undifferentiated phenotypes occurring at low TIMP4 and high TIMP1 levels has been attributed to the activation of the oncogenes yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ), which have also been associated with sarcomagenesis and maintenance of stem cell-like features in various cancer types [151,152,153]. Here, TIMP1 is linked to cancer.