MMP14, whose prominent expression is also seen in the virus-infected cells within KS tumors, was specifically identified as a key player for the virus-induced sprouting of KSHV-infected lymphatic endothelial cells in a 3D fibrin matrix and for the endothelial-to-mesenchymal reprogramming of KSHV-infected lymphatic endothelial cells [57]. Here, MMP14 is linked to Kaposi's sarcoma.