Moreover, transcriptomic data from the Cancer Genome Atlas program (TCGA) shows a significant correlation between the expression of MMP14 and the transcription factors TWIST (TWIST1: r = 0.4, p = 8.31 × 10−11; TWIST2: r = 0.21, p = 9.72 × 10−4) and SNAI (SNAI1: Pearson’s r = 0.23, p = 3.08 × 10−4; SNAI2: r = 0.21, p = 9.96 × 10−4) in sarcomas, suggesting that MMP14 expression is coupled with the transcriptional program governing the sarcoma phenotype. This evidence concerns the gene TWIST1 and sarcoma.