It is known that SP promotes the migration of tumor cells (SP favors the formation of membrane blebbing) for invasion/metastasis; that SP increased the expression of VEGF-C and matrix metalloproteinase favoring tumor metastasis; that NK-1R antagonists inhibit such an increase [70,71], and that these antagonists block the changes in the cell shape (including blebbing) induced by SP (in the latter mechanisms Rho-associated protein kinase (ROCK) was involved) (Figure 1) [72]. The gene discussed is VEGFC; the disease is neoplasm.