There is also evidence for defects in the abundance of insulin signaling and lipid metabolic proteins in maternal skeletal muscle, white adipose tissue and/or liver that may relate to altered glucose‐insulin handling and nutrient partitioning in human and rodent pregnancies associated with obesity (Barbour et al. 2007; Sferruzzi‐Perri et al. 2013b; Fernandez‐Twinn et al. 2017; Musial et al. 2017). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.