Although the initial swelling peak at 2–3 dpi, thought to be caused by edema and monocyte infiltration [53], was reduced during CHIKV-3ʹ-Cre infection, the latter and more pronounced swelling peak at 6 dpi, which is driven by infiltration of monocytes and CD4+ T cells [37,53], was equivalent between the two viruses (Fig 2A). The gene discussed is CD4; the disease is infection.