Treatment of advanced RCC has evolved with the development of targeted therapies including vascular endothelial growth factor receptor tyrosine kinase inhibitors (TKIs), such as bevacizumab, sunitinib, sorafenib, pazopanib, axitinib, cabozantinib and lenvatinib or mammalian target of rapamycin inhibitors, such as everolimus and temsirolimus [6]. This evidence concerns the gene MTOR and renal cell carcinoma.