CD4 and infection: T and B cell epitopes from IMC, ROP18 and MIC8 in multi-antigen VLPs might contribute to induce memory T and B cells responses, which result in effective CD4+, CD8+ T cell responses, antibody secreting cell responses, IgG, IgG2a, IgA antibody responses in sera or feces and complete protection against T. gondii ME49 challenge infection.