The safety and efficacy of anti-TNF therapy for the management of ocular manifestations (including scleritis) of inflammatory diseases including Behcet disease have been reported.[19,20,21] In the present case, after initial treatment with high dose systemic corticosteroids, tapering resulted in a relapse of intraocular inflammation, and combined treatment with anti-TNF-α therapy allowed safe and successful tapering prednisolone and improved visual acuity. This evidence concerns the gene TNF and scleritis.