Further, the epithelial cell adhesion molecule (EpCAM)+ subpopulation in the reprogrammed hepatocyte-like cells was significantly decreased, suggesting that cancer cell reprogramming via HNF1A, HNF4A and FOXA3 could effectively eliminate CSCs to prevent cancer recurrence, relapse, and resistance in HCC. This evidence concerns the gene FOXA3 and hepatocellular carcinoma.