In year 2015, McClellan et al. [88] found that myeloid differentiation-inducing cytokines, including FMS-like tyrosine kinase ligand (FLT3L), interleukin 7 (IL-7), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (MCSF) and myeloid transcription factors such as C/EBPα and PU.1 could efficiently reprogram primary human BCR-ABL1+ B-ALL cells into macrophage-like cells. The gene discussed is IL3; the disease is precursor B-cell acute lymphoblastic leukemia.