Then in 2019, Cheng et al. [76] demonstrated that the combination of HNF1A, HNF4A and FOXA3 could also induce direct reprogramming of HCC into hepatocyte-like cells with normal functions including albumin secretion, glycogen synthesis, low-density lipoprotein uptake as well as metabolism control and detoxification. This evidence concerns the gene FOXA3 and hepatocellular carcinoma.