Thus, Ishay-Ronen et al. induced EMT by treating Py2T breast cancer cells with transforming growth factor-beta (TGF-β) in vitro and re-differentiated the reprogrammed Py2T cells into functional adipocytes by using insulin, dexamethasone, rosiglitazone, and bone morphogenetic protein 2 (BMP2). This evidence concerns the gene TGFB1 and breast cancer.