Surprisingly, the same team reported that the secretion secreted BMP2 and TGF-β2 and triggered the expression of miR-301b-3p in HCC cells, followed by inhibition of the limbal gene expression membrane protein (LSAMP) and CYLD Lysine deubiquitinase and increased stem cell characteristics in HCC cells. Here, CYLD is linked to hepatocellular carcinoma.