HPGDS and benign prostatic hyperplasia: Furthermore, we found that the expression of genes associated to active oxygen elimination and detoxification, such as catalase (CAT), glutathione S-transferase (GST), methionine sulfoxide reductase (MSR), ferritin and carboxylesterases (CarE) [68] were significantly up-regulated in NB6-BPH relative to N-BPH (Fig. 9; Additional file 6, Table S5).