Consistent with features associated with insulin resistance in vivo, PA but not OA attenuated signaling through Akt as measured by pAkt‐S473, increased mRNA levels of the gluconeogenic enzyme glucose‐6‐phosphatase, and led to elevated ROS levels in vitro (Schmoll et al, 2000; Puigserver et al, 2003). Here, AKT1 is linked to Insulin resistance.