INS and Insulin resistance: The underlying molecular mechanisms of hepatic insulin resistance are still incompletely defined, but impaired control of gluconeogenesis is commonly linked to attenuated insulin signaling through Akt, a canonical downstream serine/threonine kinase that modulates and controls liver metabolism through several signaling cascades of kinase‐mediated protein phosphorylation (Leavens & Birnbaum, 2011; Haeusler et al, 2014).