The melanoma cell lines UACC257 and A2058 were selected for the time‐resolved phosphoproteomic study because (i) they have no measurable EDNRA expression (Renz et al, manuscript in preparation), so that EDN signalling is mediated purely through EDNRB, (ii) a CRISPR/Cas9 EDNRB knockout was available, and (iii) the system is of broad medical interest. Here, RNASE2 is linked to melanoma.