Second, Robak et al. [13] showed that the VR-CAP arm had a non-significant improvement in OS with an improved 4-year OS rate compared with the R-CHOP arm (64% vs. 54%); meanwhile, 132 patients (54%) in the R-CHOP arm and 82 patients (34%) in the VR-CAP group received subsequent anti-lymphoma therapy, and the type of subsequent therapy was generally similar in the two groups. This evidence concerns the gene DDIT3 and lymphoma.