ICAM1 and multiple sclerosis: Increased expression of ICAM1 has been demonstrated in endothelial cells, microglia, and astrocytes in patients with multiple sclerosis (Carrithers, Visintin, Kang, & Janeway, 2000; Mycko, Kwinkowski, Tronczynska, Szymanska, & Selmaj, 1998).