Including all 338 patients from series 1, and variables from univariate survival analyses (see supplementary material, Tables S3 and S4) in multivariate Cox' regression analysis, the EN‐switch was an independent predictor of time to skeletal metastases (HR 3.7, p = 0.001) and cancer specific death (HR 8.4, p < 0.0005), together with FOXC2 (HR 1.9, p = 0.057 and HR 2.0, p = 0.061), Gleason grade groups (≥GG3 [4+3] versus ≤GG2 [3+4]) and pathological stage (≥pT3 versus pT2) (see supplementary material, Table S5). This evidence concerns the gene FOXC2 and cancer.