The pivotal role of FOXC2 in prostate cancer was demonstrated by indirect suppression of FOXC2 in mice injected with a metastatic prostate cancer cell line, restoring epithelial phenotype, attenuating CSCs and, of major significance, resensitising prostate carcinoma cells to anti‐androgen and taxane therapy 50. The gene discussed is FOXC2; the disease is prostate carcinoma.