IRF9 and neoplasm: ER stress also regulates JAK signaling to affect tumor progression, such as the inhibition of STAT3‐mediated liver gluconeogenesis via dephosphorylation and deacetylation.45 ER stress regulates GH‐induced JAK2 signal transduction and the activation of STAT5 signaling.46 In the present study, activation of the ER stress signaling pathway led to increased expression of the JAK2 signaling pathway factors JAK2 and IRF9 was increased.