Previous studies reported that viral RNA can bind to the RIG‐I receptor, thereby activating the RIG‐I signaling pathway, as well as inflammatory and IRF3 signaling pathways, to induce IFN signaling and block viral invasion.17, 18, 19 Recent studies on RIG‐I in cancer have revealed that high RIG‐I expression is associated with lower survival rates in patients with pancreatic ductal carcinoma and that RIG‐I promotes cancer cell growth.20 We also demonstrated that EBER regulates inflammation via RIG‐I to promote NPC. This evidence concerns the gene IRF3 and cancer.