NEB and neoplasm: Taken together, these results suggest NEB may serve as a gateway for epithelial‐stromal interactions in advanced GC microenvironment (Fig. 3d), mediating the cross‐talk between tumorigenic pathways of epithelial and stromal tumor cells, and activating (NEB wildtype) or suppressing (NEB mutant) EMT, a critical pathway for cancerous cell dissemination.