GC epithelial cell specific carcinogenic pathways:KRAS dependencyEpithelial specific splicing factor, ESRP1/2Epithelial carcinogenic genes: HNF4A, EHF, EPCAMIntestinal microvilliar niche: VIL1 and USH1CInteractions with stromal tumor via NEB:Upregulated genes by NEB mutation coincides with M28NEB mutation correlates to low stromal scoreNEB mutation signature coincides with GIST tumorigenic pathways (i.e. KIT/PDGFRA mutations). This evidence concerns the gene ESRP1 and gastrointestinal stromal tumor.