Interestingly, TFF1 was upregulated by GKN2 overexpression (Fig. 2a,b), known synergistic heterodimeric interaction partner of GKN2 conferring antiproliferative and proapoptotic effects on gastric cancer cells.19 This suggests GKN2 alone is capable of conferring antitumor effect. The gene discussed is GKN2; the disease is gastric cancer.