NEB and goblet cell carcinoma: Together with NEB functions in maintaining cytoskeletal matrix, the downregulation of M109 in NEB mutants strongly suggests disruption of dynamic changes in actin cytoskeleton via loss‐of‐function mutation in NEB, a necessary process of EMT for cancerous cells to acquire cell motility and morphological changes.22 This also explains the underrepresentation of N3 patients in NEB mutant samples in TCGA‐GCC (Supporting Information Fig. S4c).