IL1RL1 and asthma: In other study, interleukin-1-receptor-like 1 or sST2 (a well-replicated asthma-gene and associates with eosinophilia) was compared to the API in 202 Dutch wheezing children and 50 healthy controls reporting that serum sST2 levels at 2–3 years could not distinguish which of the preschoolers developed asthma at school age; consequently, serum sST2 did not significantly add to the prediction of asthma diagnosis than the used of API (API alone vs. API+sST2: AUC = 0.60, p = 0.02 vs. AUC = 0.57, p = 0.12, respectively) (46).