CCN2 and neoplasm: The anti-tumor effects of the chimeric DNA vaccine CTGF/MSLN (containing an antigen-specific connective tissue growth factor linked to with MSLN) in combination with an anti-CD40 Ab and the TLR 3 ligand poly(I:C), which are essential adjuvants for DC maturation, the immuno-modulator EGCG and Meso-VAX in combination with (AAV)-IL-12 were proven [81].