By decreasing p52- and p65-DNA-binding activities, melatonin can transcriptionally inhibit MMP-9, and melatonin receptor 1A (MTNR1A)(high)/MMP-9(low) patients have a higher survival rate than MTNR1A(low)/MMP-9(high) RCC patients [73]. This evidence concerns the gene MMP9 and renal cell carcinoma.