TP53BP2 and renal cell carcinoma: Histone deacetylase 1 (HDAC1) inhibited the apoptosis-stimulating protein of p53-2 (ASPP2), but vorinostat, an HDAC1 inhibitor, restored ASPP2 transcription, elevated ASPP2, promoted apoptosis, inhibited the EMT and exerted a synergistic effect with 5-fluorouracil in vitro and in vivo in RCC models [80].