To date, several subtypes of RCC have been defined, of which clear cell RCC (ccRCC) is the most frequent (75–80%), followed by papillary RCC (pRCC; 15%) and chromophobe RCC (chRCC; 5%) [6], and biallelic von-Hippel Lindau (VHL) gene defects occur in approximately 75% of sporadic ccRCC [7]. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.