Immune checkpoint inhibitors, such as PD-1/PDL-1 and cytotoxic T-lymphocyte-associated antigen (CTLA-4) blockade therapies, have led to considerable changes in the treatment of several solid malignancies, including metastatic melanoma, advanced RCC (aRCC), and NSCLC. Here, PDCD1 is linked to non-small cell lung carcinoma.