NFKB1 and viral infectious disease: Normally, NF-κB remains in an inactive form in the cytoplasm and once activated by a variety of stimulants, such as cytokines, lipopolysaccharide, bacterial or viral infection, NF-κB could translocate to the nucleus and then modulate the expression of downstream target genes that participate in a number of cellular functions, including cell proliferation, apoptosis, cell migration and angiogenesis [34].