Western blot results suggested that pretreatment with specific inhibitors suppressed the activation of NF-κB and Akt signalings caused by E6 oncogene (Fig. 3h, i), implying that the effect of E6 oncogene on HNSCC cells was dependent on these signaling pathways. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.