Moreover, to investigate the effect of miR-21 on fatty acid metabolism in human non-small cell lung cancer cells, the intracellular contents of lipids and key lipid metabolic enzymes were determined and the results revealed cellular content of phospholipids, neutral lipids content, cellular content of triglycerides, and the levels of key lipid metabolic enzymes FASN, ACC1 and FABP5 were significantly increased following miR-21 mimic treatment compared with control in A549 cells. This evidence concerns the gene FABP5 and non-small cell lung carcinoma.