Western blotting analysis confirmed that overexpression of NR3C1 in GC-resistant Reh and Jurkat ALL cell lines could induce expression of the pro-apoptotic proteins Bim, Bad, Bax and Bak, and decrease expression of the anti-apoptotic proteins Bcl-2 and Bcl-xl (Fig. 4c). This evidence concerns the gene BAK1 and acute lymphoblastic leukemia.