Our results found that in melanoma skin cancer (i) NEAT1 was over-expressed, and it promoted cell proliferation, migration, and invasion; (ii) expression of miR-23a-3p was inhibited by NEAT1; (iii) the sponge between NEAT1 and miR-23a-3p could regulate melanoma proliferation; and (iv) MiR-23a-3p targeted KLF3 and NEAT1/miR-23a axis regulated melanoma proliferation, migration, and invasion via KLF3. The gene discussed is NEAT1; the disease is melanoma.