Furthermore, an in vivo T cell cytotoxic assay revealed that Sharpin-deficient T cells induced T cell-mediated colitis and resultant weight loss (Fig. 2h, i); however, they had a lower pathogenic potency and exhibited a lower percentage of activated CD25+ T cells in the mesenteric lymph nodes (Fig. 2h, j). The gene discussed is SHARPIN; the disease is colitis.