Importantly, deletion of one allele of the Hoip locus in Sharpinfl/flFoxp3Cre (Sharpinfl/flHoipfl/+Foxp3Cre) mice rendered skin inflammation more severe and, intriguingly, the T cell-poor lesions in Sharpinfl/flFoxp3Cre mice were converted to a T cell-dominant type in Sharpinfl/flHoipfl/+Foxp3Cre mice, which can be regarded as an autoimmune disease (Fig. 7e–g). The gene discussed is RNF31; the disease is autoimmune disease.