Additional elimination of Sharpin from Treg in Sharpinfl/flK5Cre mice (Sharpinfl/flK5CreFoxp3Cre) exacerbated skin inflammation, with a marked increase in caspase-3 activity in CD45neg keratinocytes, which led to earlier onset of disease (Fig. 5c–e). Here, SHARPIN is linked to dermatitis.