The ameliorated skin inflammation led to marked suppression of autoinflammation-related cytokines such as TNFα, IL-1β, and IL-6, which were elevated in cpdm skin; similar observations were made with respect to development of immunopathological hallmarks of cpdm disease, such as splenomegaly and infiltration of multiple organs by myeloid cells (Fig. 3e–g and Supplementary Fig. 3E). This evidence concerns the gene TNF and Splenomegaly.