GREB1 and neoplasm: The expression of N-cadherin, a target gene of TGFβ signaling, was lower in the tumor lesions compared with the nontumor regions of BYM mouse livers, whereas in BYM GREB1 KD mice livers, N-cadherin was upregulated in the tumor lesions and became comparable to the nontumor regions, suggesting that TGFβ signaling was activated by GREB1 depletion (Fig. 7h).