The expression of N-cadherin, a target gene of TGFβ signaling, was lower in the tumor lesions compared with the nontumor regions of BYM mouse livers, whereas in BYM GREB1 KD mice livers, N-cadherin was upregulated in the tumor lesions and became comparable to the nontumor regions, suggesting that TGFβ signaling was activated by GREB1 depletion (Fig. 7h). Here, TGFB1 is linked to neoplasm.