For example, resident fibroblast in the liver and pancreas, known as quiescent hepatic stellate cells (HSCs) and pancreatic stellate cells (PSCs), can acquire a myofibroblast-like phenotype, including α-smooth muscle actin (α-SMA) expression (which considered as CAFs in liver and pancreatic cancers, respectively) upon TGF-β and PDGF activation [21, 22]. This evidence concerns the gene ACTA1 and familial pancreatic carcinoma.