In pancreatic cancer, α-SMA+ vimentin+ glial fibrillary acidic protein+ (GFAP), CAFs secret macrophage colony-stimulating factor 1 (M-CSF), IL-6, and CC-chemokine ligand 2 (CCL2) to promote monocyte recruitment encourage macrophage differentiation and M2 polarization [55]. This evidence concerns the gene ACTA1 and familial pancreatic carcinoma.