Moreover, α-SMA+ CAF-derived IL-6 can recruit neutrophils, activate signal transducer and activator of Janus kinase-programmed cell death ligand 1 (STAT3-PDL1) signaling cascade in neutrophils, therefore, contributing to immunosuppression in hepatocellular carcinoma [63]. This evidence concerns the gene ACTA1 and hepatocellular carcinoma.