NFKB1 and neoplasm: In fact, CK1α is a multifunctional protein involved in various signaling pathways [52] including Wnt/β-catenin, Hedgehog, autophagy, NF-κB, etc. Activation of CK1α by pyrvinium also inhibited the proliferation and tumor growth via attenuation of the Hedgehog signaling pathway [53] or inhibition of autophagosome formation [54].