Consistent with the results of the upregulated proteins of B16-F10 tumour-bearing PMN-MDSCs, the results of GO analysis showed that the functions of cell proliferation, oxidation–reduction process, nucleoside metabolic process-related biological processes (Fig. 4c), NADH dehydrogenase activity, oxidoreductase activity and ATP binding-related molecule function of the PMN-MDSCs were downregulated after POG treatment (Fig. 4d). The gene discussed is ENSG00000254051; the disease is neoplasm.