Based on our findings, in order to avoid any possible bias, we established a further univariate statistical analysis on patients undergoing a 2D–3D treatment schedule, verifying the presence of any difference with respect to patients who had undergone SOF-based antiviral regimens, with respect to gender, CTP class, albumin serum level, bilirubin, INR, diabetes, liver stiffness and platelets. This evidence concerns the gene ALB and diabetes mellitus.