ADIPOQ and obesity due to melanocortin 4 receptor deficiency: To support this finding, previous study reported there was no changes in the adiponectin mRNA expressions from adipocytes in high fat diet induced obesity Wistar rat after treatment with the mixture of extract herbal medicines consisting of Benincasae semen, Laminaria japonica Areschon., Pini Folium, Moli Folium, Citrus aurantium Linn., and Ephedra herb [54].