However, the detailed mechanism of NPM1 as a proliferation enhancer in cancer cells should be evaluated in future studies; several hypotheses have been proposed, including that NPM1 is a putative stimulatory factor for DNA polymerase-α (DNA Polα) or that NPM1 interacts with and inhibits p53 in response to apoptotic stimuli [40]. The gene discussed is NPM1; the disease is cancer.