DECLARE-TIMI 58 [14] confirmed the benefit of reduction in HF hospitalisation with SGLT-2 inhibitors, but did not show a significantly lower rate of MACE which contrasted with the findings from the EMPA-REG OUTCOME [10], CANVAS [15] and CANVAS-R [15] trials (Table 1, Additional file 1: Table S15). Here, SLC5A2 is linked to hydrops fetalis.