As the oxygen concentration is critical for cancer cell energy metabolism and both, the MAPK/ERK pathway and MITF signaling, have been associated with the control of metabolic activities of melanoma cells [27], the selection of DMBC12 cells (BRAFV600E/MITFlow), DMBC28 cells (BRAFV600E/MITFhigh) and DMBC17 (HRASQ61R/MITFhigh) [30,31] for this study was well justified. This evidence concerns the gene MITF and cancer.