Our results support and extend these findings as a tendency of drug-triggered PGC1α downregulation in samples with greater PARP cleavage was observed, which might indicate that the stability of this protein can be connected with induction of apoptosis, especially in melanoma cells with lower expression of PGC1α, DMBC28 and DMBC17 (Figure 6). Here, PPARGC1A is linked to melanoma.