The second multivariate model incorporating baseline tumor burden, Alb and ΔAlb at week 4, tumor burden of 11 or less (OR 22, p = 0.004), baseline Alb <3.8 g/dL (OR 12, p = 0.02), and ΔAlb at week 4 <0.1 g/dL (OR 4.8, p = 0.04) were significant (Table 4, multivariate model 2). The gene discussed is ALB; the disease is neoplasm.