DM1 is a multisystemic disorder disease caused by abnormal mRNA splicing, which is induced by the expanded CTG repeat in dystrophic myotonic protein kinase (DMPK), while DM2 is caused by CCTG repeat expansion in the first intron of the CCHC-type zinc finger nucleic acid binding protein (CNBP) [83]. This evidence concerns the gene CNBP and myotonic dystrophy type 2.