NFKB1 and brain edema: On the other hand, pretreatment of 1,2-DCE-intoxicated mice with PDTC, a specific inhibitor of NF-κB, dose-dependently attenuated the changes in NF-κB binding activities, brain water content, and pathological observation of brain edema, suggesting that activation of NF-κB was involved in 1,2-DCE-induced brain edema in mice.