CSF3 and Decreased total neutrophil count: Granulocyte colony stimulating factors (G-CSF) such as filgrastim may be appropriate in patients with poor prognostic factors (presence of sepsis, age over 65 years, severe neutropenia, or multiple comorbidities), as it may hasten the recovery of WBCs and shorten the duration of hospitalization and antibiotic therapy [40,41].