HMOX1 and stroke disorder: In a study conducted on experimental stroke-induced mice to investigate the neuroprotective effects of this flavonoid, it was found that isorhamnetin at 5 mg/kg improved the blood brain barrier (BBB) function, upregulated Nrf2/HO-1, downregulated NR1, reduced oxidative stress, inflammation, cerebral edema, NO production and suppressed iNOS (Figure 4).