This observation is most likely in agreement with the low frequency of PSGL-1 expression on ALL blasts (Figure 1B) or a deficient post-translational modification of PSGL-1 and, in contrast to AML blasts, suggests that E-selectin ligands may play a critical role, in the majority of ALL, in promoting primary lymphoblast adhesion to endothelial selectins. The gene discussed is SELE; the disease is acute myeloid leukemia.