Monoclonal MMP-9 antibody AB0046, which inhibited tumor growth and metastasis in a surgical orthotopic xenograft model of colorectal carcinoma [72], improved immune responses to tumors, as the inhibition of MMP-9 reversed MMP-9 inactivation of T-cell chemoattractant CXCR3 ligands (CXCL9, CXCL10, and CXCL11) [198]. Here, MMP9 is linked to colorectal carcinoma.