The absence of a positive correlation between OSM and ICAM-1, E-selectin and P-selectin may be caused by statin use in the AGES‐Reykjavik study (approx. 22%)[21], as statins reduce ICAM-1, E-selectin and P-selectin plasma levels in patients with coronary artery disease[32]. This evidence concerns the gene SELE and coronary artery disorder.