Also, it is important to highlight that PKM2 expression can be influenced by different signalling pathways, which can be stimulated by the tumour microenvironment (hypoxia and nutrient status), mutations, growth factors (it is described that the PKM2 function and/or transcription is influenced by the signalling of tyrosine kinase receptors as EGFR) and hormones [61], what can be related with our data. This evidence concerns the gene PKM and neoplasm.