PKM and cancer: Although several are the genes associated with HBC, in this study, we have chosen a specific set of cancer-related genes as such: TP53, CCND1, FUS, YBX1, PTBP1, c-MYC and PKM2. This cancer gene panel was selected based on the following assumptions: the information in FMCs about these genes is scarce or inexistent; these genes are conserved between cat and human; the function of these genes that is ascribed in HBC; and the pathways in which the products of these genes are involved, establishing a molecular cancer network that is important to analyse as a whole.