CDCP1 and neoplasm: As compared to the CDCP1– fraction in muKras tumor cells (DKs5 and HK2-10), CDCP1+ CSCs exhibited relatively lower levels of intracellular ROS, accompanied with remarkably higher levels of the [NADPH/NADP+] and [glutathione/glutathione disulfide] ([GSH/GSSG]) ratios (Fig 3A).