This activity of Bcr has mostly been described in the context of the p210bcr-abl fusion from the Philadelphia chromosome that is associated with virtually all cases of chronic myeloid leukemia, and activates RhoA and various downstream targets thereof (Rochelle et al., 2013; Tala et al., 2013). Here, RHOA is linked to chronic myelogenous leukemia, BCR-ABL1 positive.